Treatment-resistant depression (TRD) is a form of depression that persists despite trying multiple treatments. Despite medication, therapy, or other interventions, individuals with TRD may continue to experience persistent symptoms such as low mood, lack of energy, and diminished interest in daily activities. Coping with TRD can be challenging, but exploring alternative treatments, adjusting medication regimens, and considering Spravato treatments or transcranial magnetic stimulation (TMS) may offer hope for improvement. It's essential for individuals with TRD to work closely with mental health professionals to tailor a comprehensive treatment plan that addresses their unique needs. While TRD can be a formidable challenge, ongoing support and perseverance can pave the way toward better mental health and an improved quality of life.